Neurodegeneration of the human brain can lead to a series of diseases, such as Alzheimer's disease, and mesenchymal stem cells ( MSCs) can help Alzheimer's patients with nerve repair, thus achieving the effect of treatment of the disease. MSCs have high self-renewal ability, multi-directional differentiation potential, low immunogenicity and immunomodulatory ability, and still have the potential of multi-directional differentiation after many passages.

Previous studies have shown that the role of MSCs in the treatment of central nervous system diseases has been confirmed. As early as 2000, Woodbury and others have successfully induced rat and human bone marrow MSCs to differentiate into neurons and glial cells in vitro. Since then, Shakhbazau et al have found that bone marrow MSCs can differentiate into neuron-like cells in vivo and express specific markers. The possible mechanisms of MSCs in the treatment of central nervous system injury include the secretion of nerve and vascular growth factors, the promotion of nerve axonal regeneration and construction, and the formation of neovascularization. BMSCs plays an important role in the treatment of brain trauma (Traumatic brain injury, TBI), spinal cord injury (SCI)), neurodegenerative diseases (Huntington's chorea, Alzheimer's disease) and so on.

In April 2020, Professor Li Jiujun of Shengjing Hospital of China Medical University jointly studied and published the article " Marrow-derived mesenchymal stem cells regulate the inflammatory response and repair alveolar type II epithelial cells in acute lung injury of rat" with Baofeng Biology, with Dr. Chen Xianyang of Baofeng Biology as the co-first author. In this study, mesenchymal stem cell technology was used to explore the repair role of mesenchymal stem cells in acute lung injury and to verify that the injury of alveolar type Ⅱ epithelial cells was alleviated. This technique and results can not only be used in acute lung injury and COVID-19 prognosis repair in the future, but also lay a foundation for mesenchymal stem cells in nervous system repair and treatment of degenerative diseases.

Although the efficacy of mesenchymal stem cells in the treatment of central system diseases has been confirmed in animal experiments, this treatment lacks long-term effect, and the survival rate of transplanted cells is too low. it is impossible to cure the disease only by temporarily protecting the transplanted cells and nourishing the nerves. Therefore, Baofeng Biology and Li Jiujun Research Group of Shengjing Hospital, on the basis of mesenchymal stem cell research cooperation, continue to carry out the project "Research on the Mechanism of Nervonic acid in hypoxic-Ischemic brain damage at High altitude". This paper expounds the action mechanism of nervonic acid in the brain, and provides a theoretical basis for the clinical treatment of neurotic acid in brain injury at high altitude. Nervonic acid, as an important component of the nerve cell membrane, is the main structure on the skeleton branch chain of complex lipids (gangliosides, brain glycosides, sphingomyelin), which is involved in the metabolism and repair of nerve cells. Nervonic acid can be supplemented directly in vitro, which effectively makes up for the defects in the use of mesenchymal stem cell technology.

Baofeng Biotechnology (Beijing) Co., Ltd., as a biotechnology company specializing in the detection of nervous system diseases, as well as the research, development, production, sales and technical services of brain health products, will focus on the external intervention of mesenchymal stem cells in the future. and nervonic acid involved in cell repair, in-depth research and application, to provide new ideas and new means for the research and treatment of nervous system diseases.